Unknown

Dataset Information

0

Uremic toxins are conditional danger- or homeostasis-associated molecular patterns.


ABSTRACT: We mined novel uremic toxin (UT) metabolomics/gene databases, and analyzed the expression changes of UT receptors and UT synthases in chronic kidney disease (CKD) and cardiovascular disease (CVD). We made the following observations: 1) UTs represent only 1/80th of human serum small-molecule metabolome; 2) Some UTs are increased in CKD and CVD; 3) UTs either induce or suppress the expression of inflammatory molecules; 4) The expression of UT genes is significantly modulated in CKD patients, and coronary artery disease (CAD) patients; 5) The expression of UT genes is upregulated by caspase-1 and TNF-alpha pathways but is inhibited in regulatory T cells. These results demonstrate that UTs are selectively increased, and serve as danger signal-associated molecular patterns (DAMPs) and homeostasis-associated molecular patterns (HAMPs) that modulate inflammation. These results also show that some UT genes are upregulated in CKD and CAD via caspase-1/inflammatory cytokine pathways, rather than by purely passive accumulation.

SUBMITTER: Sun Y 

PROVIDER: S-EPMC5627515 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Uremic toxins are conditional danger- or homeostasis-associated molecular patterns.

Sun Yu Y   Johnson Candice C   Zhou Jun J   Wang Luqiao L   Li Ya-Feng YF   Lu Yifan Y   Nanayakkara Gayani G   Fu Hangfei H   Shao Ying Y   Sanchez Claudette C   Yang William Y WY   Wang Xin X   Choi Eric T ET   Li Rongshan R   Wang Hong H   Yang Xiao-Feng XF  

Frontiers in bioscience (Landmark edition) 20180101 2


We mined novel uremic toxin (UT) metabolomics/gene databases, and analyzed the expression changes of UT receptors and UT synthases in chronic kidney disease (CKD) and cardiovascular disease (CVD). We made the following observations: 1) UTs represent only 1/80<sup>th</sup> of human serum small-molecule metabolome; 2) Some UTs are increased in CKD and CVD; 3) UTs either induce or suppress the expression of inflammatory molecules; 4) The expression of UT genes is significantly modulated in CKD pati  ...[more]

Similar Datasets

| S-EPMC7311766 | biostudies-literature
| S-EPMC7309510 | biostudies-literature
| S-EPMC4197774 | biostudies-literature
| S-EPMC5413532 | biostudies-literature
| S-EPMC8474429 | biostudies-literature
| S-EPMC7354618 | biostudies-literature
| S-EPMC2768518 | biostudies-literature
| S-EPMC4886219 | biostudies-literature
| S-EPMC6938492 | biostudies-literature
| S-EPMC8792216 | biostudies-literature