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Self-assembling soft structures for intracellular NO release and promotion of neurite outgrowth.

ABSTRACT: Nitric oxide (NO), an endogenously produced free radical species, is an extremely important signalling molecule in several biochemical processes related to neurotransmission, neuronal communication, and vasodilation, to name a few. Other than relying on endogenous synthesis, intracellular NO delivery presents an interesting challenge to fully exploit the therapeutic potential of this gaseous molecule. We have applied a self-assembling peptide conjugate strategy to devise a construct carrying a NO-release arm, which can be activated under standard redox conditions. Consequently, a tryptophan-based peptide carrier was designed, which self-assembled in the solution phase to afford soft nanospherical structures, and released NO in Neuro2a cell line, resulting in neurite outgrowth.

SUBMITTER: Pal HA

PROVIDER: S-EPMC5627600 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Self-assembling soft structures for intracellular NO release and promotion of neurite outgrowth.

Pal Hilal Ahmad HA Mohapatra Saswat S Gupta Varsha V Ghosh Surajit S Verma Sandeep S

Chemical science 20170620 9

Nitric oxide (NO), an endogenously produced free radical species, is an extremely important signalling molecule in several biochemical processes related to neurotransmission, neuronal communication, and vasodilation, to name a few. Other than relying on endogenous synthesis, intracellular NO delivery presents an interesting challenge to fully exploit the therapeutic potential of this gaseous molecule. We have applied a self-assembling peptide conjugate strategy to devise a construct carrying a N ...[more]

PMID: 28989648

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