Hippocampal volume changes following electroconvulsive therapy: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Reduced hippocampal volume is one of the most consistent morphological findings in Major Depressive Disorder (MDD). Electroconvulsive therapy (ECT) is the most effective therapy for MDD, yet its mechanism of action remains poorly understood. Animal models show that ECT induces several neuroplastic processes, which lead to hippocampal volume increases. We conducted a meta-analysis of ECT studies in humans to investigate its effects on hippocampal volume.

Methods

PubMed was searched for studies examining hippocampal volume before and after ECT. A random-effects model was used for meta-analysis with standardized mean difference (SMD) of the change in hippocampal volume before and after ECT as the primary outcome. Nine studies involving 174 participants were include

SUBMITTER: Wilkinson ST 

PROVIDER: S-EPMC5627663 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature