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Revision of the concept of anti-angiogenesis and its applications in tumor treatment.

ABSTRACT: Anti-angiogenesis therapy, by blocking formation of new blood vessels in tumors, is the standard-of-care therapy for various cancer types. The classic concept of anti-angiogenesis is expected to turn a tumor into a "dormant" disease. However, the combination of anti-angiogenesis agents with conventional therapeutics has generally produced only modest survival benefits for cancer patients in clinical trials. Therefore, the concept and applications of anti-angiogenesis have evolved dramatically along with lessons learned from recent clinical experience. In this article, we will discuss the revised concept of anti-angiogenesis therapy and the applications of anti-angiogenesis drugs, and focus particularly on how to utilize current anti-angiogenesis agents and develop new approaches to provide more benefits to patients with cancer.

SUBMITTER: Yang WH

PROVIDER: S-EPMC5627689 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Revision of the concept of anti-angiogenesis and its applications in tumor treatment.

Yang Wen-Hui WH Xu Jun J Mu Jian-Bing JB Xie Jun J

Chronic diseases and translational medicine 20170308 1

Anti-angiogenesis therapy, by blocking formation of new blood vessels in tumors, is the standard-of-care therapy for various cancer types. The classic concept of anti-angiogenesis is expected to turn a tumor into a "dormant" disease. However, the combination of anti-angiogenesis agents with conventional therapeutics has generally produced only modest survival benefits for cancer patients in clinical trials. Therefore, the concept and applications of anti-angiogenesis have evolved dramatically al ...[more]

PMID: 29063054

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