Vitamin D and methylarginines in chronic kidney disease (CKD).

ABSTRACT:

Background

Vitamin D associates with the plasma concentration of the endogenous inhibitor of the nitric oxide system asymmetric dimethyl arginine (ADMA) and cross-sectional studies in CKD patients treated with the vitamin D receptor activator paricalcitol show that plasma ADMA is substantially less than in those not receiving this drug.

Methods

In the frame of a randomized, double-blind, placebo controlled trial, the Paracalcitol and ENdothelial fuNction in chronic kidneY disease (PENNY), we investigated whether vitamin D receptor activation by paricalcitol (2 μg/day x 12 weeks) affects the plasma concentration of ADMA and symmetric dimethyl arginine (SDMA) in 88 patients with stage 3 to 4 CKD.

Results

Paricalcitol produced the expected small rise in serum calcium and

SUBMITTER: Torino C 

PROVIDER: S-EPMC5627906 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature