Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension.
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SUBMITTER: da Silva Goncalves Bos D
PROVIDER: S-EPMC5628179 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension.
da Silva Gonçalves Bos Denielli D Happé Chris C Schalij Ingrid I Pijacka Wioletta W Paton Julian F R JFR Guignabert Christophe C Tu Ly L Thuillet Raphaël R Bogaard Harm-Jan HJ van Rossum Albert C AC Vonk-Noordegraaf Anton A de Man Frances S FS Handoko M Louis ML
JACC. Basic to translational science 20170201 1
Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppress ...[more]
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