Ontology highlight
ABSTRACT:
SUBMITTER: Zape JP
PROVIDER: S-EPMC5628647 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Zape Joan P JP Lizama Carlos O CO Cautivo Kelly M KM Zovein Ann C AC
Cell cycle (Georgetown, Tex.) 20170818 19
The emergence of haematopoietic stem and progenitor cells (HSPCs) from hemogenic endothelium results in the formation of sizeable HSPC clusters attached to the vascular wall. We evaluate the cell cycle and proliferation of HSPCs involved in cluster formation, as well as the molecular signatures from their initial appearance to the point when cluster cells are capable of adult engraftment (definitive HSCs). We uncover a non-clonal origin of HSPC clusters with differing cell cycle, migration, and ...[more]