Ontology highlight
ABSTRACT:
SUBMITTER: Zhu KP
PROVIDER: S-EPMC5628795 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Zhu Kun-Peng KP Ma Xiao-Long XL Zhang Chun-Lin CL
Molecular therapy : the journal of the American Society of Gene Therapy 20170705 10
Recent findings have shown that lncRNA dysregulation is involved in many cancers, including osteosarcoma (OS). In a previous study, we reported a novel lncRNA, ODRUL, that could promote doxorubicin resistance in OS. We now report the function and underlying mechanism of ODRUL in regulating OS progression. We show that ODRUL is upregulated in OS tissues and cell lines and correlates with poor prognosis. ODRUL knockdown significantly inhibits OS cell proliferation, migration, invasion, and tumor g ...[more]