Retinal pathology in the PPCD1 mouse.
Ontology highlight
ABSTRACT:
SUBMITTER: Shen AL
PROVIDER: S-EPMC5628829 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Retinal pathology in the PPCD1 mouse.
Shen Anna L AL Moran Susan M SM Glover Edward A EA Teixeira Leandro B LB Bradfield Christopher A CA
PloS one 20171005 10
Retinal phenotypes of the PPCD1 mouse, a mouse model of posterior polymorphous corneal dystrophy, have been characterized. PPCD1 mice on the DBA/2J background (D2.Ppcd1) have previously been reported to develop an enlarged anterior chamber due to epithelialization and proliferation of the corneal endothelium and subsequent blockage of the iridocorneal angle. Results presented here show that D2.Ppcd1 mice develop increased intraocular pressure (IOP), with measurements at three months of age revea ...[more]
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