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One-Pot Synthesis of Polypyrazoles by Click Reactions.

ABSTRACT:

Abastract

We developed an efficient one-pot metal-free click polymerization procedure for the synthesis of 3,5-disubstituted polypyrazoles with high yields, high molecular weights, and narrow molecular weight distribution. The method involved two click reactions in a one-pot synthesis. The first reaction was the carbonyl chemistry of "non-aldol" type (condensation reaction of aldehydes with p-toluenesulfonylhydrazide), and the second was a click polymerization reaction of diazo compounds with alkynes. The reactions occurred sequentially by adding the reactants step by step. The diazo compound needed for the second click reaction was generated in situ by the first click reaction. The structures of the polypyrazoles were characterized by IR and ¹H NMR analyses. And their thermal properties and solubility were also tested.

SUBMITTER: Wang S

PROVIDER: S-EPMC5629195 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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One-Pot Synthesis of Polypyrazoles by Click Reactions.

Wang Shasha S Cheng Bin B

Scientific reports 20171005 1

<h4>Abastract</h4>We developed an efficient one-pot metal-free click polymerization procedure for the synthesis of 3,5-disubstituted polypyrazoles with high yields, high molecular weights, and narrow molecular weight distribution. The method involved two click reactions in a one-pot synthesis. The first reaction was the carbonyl chemistry of "non-aldol" type (condensation reaction of aldehydes with p-toluenesulfonylhydrazide), and the second was a click polymerization reaction of diazo compounds ...[more]

PMID: 28983109

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