Ontology highlight
ABSTRACT:
SUBMITTER: De-Marco V
PROVIDER: S-EPMC5629736 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
De-Marco Viviani V Carvalho Luciani R LR Guzzo Mariana F MF Oliveira Paulo S L PSL Gomes Larissa G LG Mendonca Berenice B BB
Clinics (Sao Paulo, Brazil) 20171001 9
<h4>Objectives</h4>Pituitary-dependent hyperadrenocorticism is the most common cause of naturally occurring hypercortisolism in dogs. CRHR1 expression in human and dog corticotrophinomas suggested that this gene affects pituitary tumorigenesis. The present study aimed to investigate mutations in the CRHR1 coding region in poodles with pituitary-dependent hyperadrenocorticism.<h4>Methods</h4>Fifty poodles with pituitary-dependent hyperadrenocorticism and 50 healthy poodles were studied. Genomic D ...[more]