Ontology highlight
ABSTRACT:
SUBMITTER: Akhurst RJ
PROVIDER: S-EPMC5630004 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cold Spring Harbor perspectives in biology 20171003 10
Transforming growth factor βs (TGF-βs) are closely related ligands that have pleiotropic activity on most cell types of the body. They act through common heterotetrameric TGF-β type II and type I transmembrane dual specificity kinase receptor complexes, and the outcome of signaling is context-dependent. In normal tissue, they serve a role in maintaining homeostasis. In many diseased states, particularly fibrosis and cancer, TGF-β ligands are overexpressed and the outcome of signaling is diverted ...[more]