Ontology highlight
ABSTRACT:
SUBMITTER: Johnson DC
PROVIDER: S-EPMC5630010 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Blood 20170821 14
Recent studies suggest that the evolutionary history of a cancer is important in forecasting clinical outlook. To gain insight into the clonal dynamics of multiple myeloma (MM) and its possible influence on patient outcomes, we analyzed whole exome sequencing tumor data for 333 patients from Myeloma XI, a UK phase 3 trial and 434 patients from the CoMMpass study, all of which had received immunomodulatory drug (IMiD) therapy. By analyzing mutant allele frequency distributions in tumors, we found ...[more]