Identification of senescent cell surface targetable protein DPP4.
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ABSTRACT:
SUBMITTER: Kim KM
PROVIDER: S-EPMC5630018 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Identification of senescent cell surface targetable protein DPP4.
Kim Kyoung Mi KM Noh Ji Heon JH Bodogai Monica M Martindale Jennifer L JL Yang Xiaoling X Indig Fred E FE Basu Sandip K SK Ohnuma Kei K Morimoto Chikao C Johnson Peter F PF Biragyn Arya A Abdelmohsen Kotb K Gorospe Myriam M
Genes & development 20170801 15
Senescent cell accumulation in aging tissues is linked to age-associated diseases and declining function, prompting efforts to eliminate them. Mass spectrometry analysis revealed that DPP4 (dipeptidyl peptidase 4) was selectively expressed on the surface of senescent, but not proliferating, human diploid fibroblasts. Importantly, the differential presence of DPP4 allowed flow cytometry-mediated isolation of senescent cells using anti-DPP4 antibodies. Moreover, antibody-dependent cell-mediated cy ...[more]
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