Ontology highlight
ABSTRACT:
SUBMITTER: Chen B
PROVIDER: S-EPMC5630194 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Chen Biaobang B Zhang Zhihua Z Sun Xiaoxi X Kuang Yanping Y Mao Xiaoyan X Wang Xueqian X Yan Zheng Z Li Bin B Xu Yao Y Yu Min M Fu Jing J Mu Jian J Zhou Zhou Z Li Qiaoli Q Jin Li L He Lin L Sang Qing Q Wang Lei L
American journal of human genetics 20170928 4
Oocyte maturation arrest results in female infertility, but the genetic determinants of human oocyte maturation arrest remain largely unknown. Previously, we identified TUBB8 mutations responsible for human oocyte maturation arrest, indicating the important role of genetic factors in the disorder. However, TUBB8 mutations account for only around 30% of individuals with oocyte maturation arrest; thus, the disorder is likely to involve other genetic factors that are as yet unknown. Here, we initia ...[more]