RASAL1 is a potent regulator of hepatic stellate cell activity and liver fibrosis.
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ABSTRACT:
SUBMITTER: Takata A
PROVIDER: S-EPMC5630295 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
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RASAL1 is a potent regulator of hepatic stellate cell activity and liver fibrosis.
Takata Akemi A Otsuka Motoyuki M Kishikawa Takahiro T Yamagami Mari M Ishibashi Rei R Sekiba Kazuma K Suzuki Tatsunori T Ohno Motoko M Yamashita Yui Y Abe Takaya T Masuzaki Ryota R Ikenoue Tsuneo T Koike Kazuhiko K
Oncotarget 20170504 39
Liver fibrosis, leading to cirrhosis and liver failure, can occur after chronic liver injury. The transition of hepatic stellate cells (HSCs) from quiescent cells into proliferative and fibrogenic cells is a central event in liver fibrosis. Here, we show that RAS protein activator like-1 (RASAL1), a RAS-GTPase-activating protein, which switches off RAS activity, is significantly decreased during HSC activation, and that HSC activation can be antagonized by forced expression of the RASAL1 protein ...[more]
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