Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC5630414 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Wang Xiaojing X Xu Tianyuan T Gao Fengbin F He Hongchao H Zhu Yu Y Shen Zhoujun Z
Oncotarget 20170807 39
Urothelial bladder cancer (UBC) is the most common urinary neoplasm in China. CCN family protein 2 (CCN2), a cysteine-rich matricellular protein, is abnormally expressed in several cancer types and involved in tumor progression or chemo-resistance. However, detailed expression patterns and effects of CCN2 in UBC still remain unknown. We found that down-regulation of CCN2 suppressed proliferation, migration and invasion of UBC cells <i>in vitro</i> and targeting of CCN2 decelerated xenograft grow ...[more]