Counterbalancing anti-adhesive effects of Tenascin-C through fibronectin expression in endothelial cells.
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ABSTRACT:
SUBMITTER: Radwanska A
PROVIDER: S-EPMC5630602 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Counterbalancing anti-adhesive effects of Tenascin-C through fibronectin expression in endothelial cells.
Radwanska Agata A Grall Dominique D Schaub Sébastien S Divonne Stéphanie Beghelli-de la Forest SBF Ciais Delphine D Rekima Samah S Rupp Tristan T Sudaka Anne A Orend Gertraud G Van Obberghen-Schilling Ellen E
Scientific reports 20171006 1
Cellular fibronectin (FN) and tenascin-C (TNC) are prominent development- and disease-associated matrix components with pro- and anti-adhesive activity, respectively. Whereas both are present in the tumour vasculature, their functional interplay on vascular endothelial cells remains unclear. We have previously shown that basally-oriented deposition of a FN matrix restricts motility and promotes junctional stability in cultured endothelial cells and that this effect is tightly coupled to expressi ...[more]
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