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Modular Approach to pseudo-Neoclerodanes as Designer ?-Opioid Ligands.

ABSTRACT: Informed by previous semisynthetic work on salvinorin A, a modular total synthesis has been developed capable of producing novel compounds targeting the ?-opioid receptor. The strategy has permitted the deliberate simplification and introduction of functionality about the target molecule to provide access to molecular features on salvinorin A otherwise unattainable by semisynthesis. Using this approach, a potent pseudo-neoclerodane ?-opioid receptor ligand (2) has been realized.

SUBMITTER: Sherwood AM

PROVIDER: S-EPMC5632227 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Modular Approach to pseudo-Neoclerodanes as Designer κ-Opioid Ligands.

Sherwood Alexander M AM Williamson Samuel E SE Crowley Rachel S RS Abbott Logan M LM Day Victor W VW Prisinzano Thomas E TE

Organic letters 20170914 19

Informed by previous semisynthetic work on salvinorin A, a modular total synthesis has been developed capable of producing novel compounds targeting the κ-opioid receptor. The strategy has permitted the deliberate simplification and introduction of functionality about the target molecule to provide access to molecular features on salvinorin A otherwise unattainable by semisynthesis. Using this approach, a potent pseudo-neoclerodane κ-opioid receptor ligand (2) has been realized. ...[more]

PMID: 28910112

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