Ontology highlight
ABSTRACT:
SUBMITTER: Parker CG
PROVIDER: S-EPMC5632530 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Parker Christopher G CG Galmozzi Andrea A Wang Yujia Y Correia Bruno E BE Sasaki Kenji K Joslyn Christopher M CM Kim Arthur S AS Cavallaro Cullen L CL Lawrence R Michael RM Johnson Stephen R SR Narvaiza Iñigo I Saez Enrique E Cravatt Benjamin F BF
Cell 20170119 3
Advances in the synthesis and screening of small-molecule libraries have accelerated the discovery of chemical probes for studying biological processes. Still, only a small fraction of the human proteome has chemical ligands. Here, we describe a platform that marries fragment-based ligand discovery with quantitative chemical proteomics to map thousands of reversible small molecule-protein interactions directly in human cells, many of which can be site-specifically determined. We show that fragme ...[more]