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Data on microcirculatory parameters of GTS- 21 treated rats assessed by intravital microscopy.


ABSTRACT: This article contains animal experimental data associated with the research article entitled "GTS-21 reduces microvascular permeability during experimental endotoxemia" (Schmidt et al., 2017) [1] (supplementary datasets of baseline intravital microscopic measurements, baseline TNF-? levels and vital parameters of the evaluated experimental groups are provided). Beneficial anti-inflammatory effects of cholinergic mediators on microvascular inflammation have been demonstrated by intravital microscopic investigations (Schmidt et al., 2015) [2], therefore we evaluated the effect of the cholinergic mediator GTS-21 on microcirculatory alterations during endotoxemia [1]. The data regarding microcirculatory effects of GTS-21 treatment ((3-(2,4-Dimethoxybenzylidene)-anabaseine dihydrochloride; 1 mg/kg; i.v.) in non-endotoxemic animals are presented in this article.

SUBMITTER: Schmidt K 

PROVIDER: S-EPMC5633251 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Data on microcirculatory parameters of GTS- 21 treated rats assessed by intravital microscopy.

Schmidt Karsten K   Bhakdisongkhram Sukanya S   Uhle Florian F   Philipsenburg Christoph C   Zivkovic Aleksandar R AR   Brenner Thorsten T   Motsch Johann J   Weigand Markus A MA   Hofer Stefan S  

Data in brief 20170923


This article contains animal experimental data associated with the research article entitled "GTS-21 reduces microvascular permeability during experimental endotoxemia" (Schmidt et al., 2017) [1] (supplementary datasets of baseline intravital microscopic measurements, baseline TNF-α levels and vital parameters of the evaluated experimental groups are provided). Beneficial anti-inflammatory effects of cholinergic mediators on microvascular inflammation have been demonstrated by intravital microsc  ...[more]

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