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Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date.


ABSTRACT: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the latest therapeutic strategy in the treatment of type 2 diabetes mellitus (T2DM). Using an insulin-independent mechanism (glycosuria), they reduce glucose toxicity and improve insulin sensitivity and ?-cell function. The promising results obtained in clinical trials show that SGLT2 significantly improves glycemic control and provides greater cardiovascular protection, combined with a reduction in body weight and blood pressure (BP). This review focuses on ertugliflozin, a new, highly selective, and reversible SGLT2 inhibitor. Clinical trials published to date show that ertugliflozin, both as a monotherapy and as an add-on to oral antidiabetic agents, is safe and effective in reducing glycosylated hemoglobin (HbA1c), body weight, and BP in T2DM patients.

SUBMITTER: Cinti F 

PROVIDER: S-EPMC5633300 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Spotlight on ertugliflozin and its potential in the treatment of type 2 diabetes: evidence to date.

Cinti Francesca F   Moffa Simona S   Impronta Flavia F   Cefalo Chiara Ma CM   Sun Vinsin A VA   Sorice Gian Pio GP   Mezza Teresa T   Giaccari Andrea A  

Drug design, development and therapy 20171003


Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the latest therapeutic strategy in the treatment of type 2 diabetes mellitus (T2DM). Using an insulin-independent mechanism (glycosuria), they reduce glucose toxicity and improve insulin sensitivity and β-cell function. The promising results obtained in clinical trials show that SGLT2 significantly improves glycemic control and provides greater cardiovascular protection, combined with a reduction in body weight and blood pressure (BP). This r  ...[more]

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