Preclinical studies modeling deep brain stimulation for depression.
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ABSTRACT:
SUBMITTER: Hamani C
PROVIDER: S-EPMC5633367 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
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Preclinical studies modeling deep brain stimulation for depression.
Hamani Clement C Nobrega José N JN
Biological psychiatry 20120629 11
Deep brain stimulation (DBS) is currently being investigated for the treatment of depression. Results of early clinical trials have been very promising, but the mechanisms responsible for the effects of DBS are still unknown. This article reviews behavioral findings of stimulation applied to different brain targets in rodents, with a particular focus on the ventromedial prefrontal cortex. Mechanisms and substrates involved in the antidepressant-like effects of DBS, including the role of local ti ...[more]
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