Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins.
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ABSTRACT:
SUBMITTER: Gao J
PROVIDER: S-EPMC5633853 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
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Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins.
Gao Jian J Zhou Zhifang Z Guo Jiatong J Guo Zhongwu Z
Chemical communications (Cambridge, England) 20170601 46
A convergent strategy was developed for the first-time synthesis of biotin-labeled GPI core glycans. These GPI conjugates are useful for various biological studies showcased by their application in the scrutiny of pore-forming bacterial toxin-GPI interaction, revealing that the phosphate group at the GPI inositol 1-O-position had a significant impact on GPI-toxin binding. ...[more]
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