Ontology highlight
ABSTRACT:
SUBMITTER: Nakatani Y
PROVIDER: S-EPMC5633920 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Nakatani Yoshio Y Jiao Wanting W Aragão David D Shimaki Yosuke Y Petri Jessica J Parker Emily J EJ Cook Gregory M GM
Acta crystallographica. Section F, Structural biology communications 20170923 Pt 10
Type II NADH:quinone oxidoreductase (NDH-2) is a respiratory enzyme found in the electron-transport chain of many species, with the exception of mammals. It is a 40-70 kDa single-subunit monotopic membrane protein that catalyses the oxidation of NADH and the reduction of quinone molecules via the cofactor FAD. NDH-2 is a promising new target for drug development given its essential role in many bacterial species and intracellular parasites. Only two bacterial NDH-2 structures have been reported ...[more]