Coronary collateralization shows sex and racial-ethnic differences in obstructive artery disease patients.

ABSTRACT:

Background

Coronary collateral circulation protects cardiac tissues from myocardial infarction damage and decreases sudden cardiac death. So far, it is unclear how coronary collateralization varies by race-ethnicity groups and by sex.

Methods

We assessed 868 patients with obstructive CAD. Patients were assessed for collateral grades based on Rentrop grading system, as well as other covariates. DNA samples were genotyped using the Affymetrix 6.0 genotyping array. To evaluate genetic contributions to collaterals, we performed admixture mapping using logistic regression with estimated local and global ancestry.

Results

Overall, 53% of participants had collaterals. We found difference between sex and racial-ethnic groups. Men had higher rates of collaterals than women (P-

SUBMITTER: Liu Z 

PROVIDER: S-EPMC5634541 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature