Ontology highlight
ABSTRACT:
SUBMITTER: An YJ
PROVIDER: S-EPMC5635000 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
An Young Jun YJ Rowland Sara E SE Na Jung-Hyun JH Spigolon Dario D Hong Seung Kon SK Yoon Yeo Joon YJ Lee Jung-Hyun JH Robb Frank T FT Cha Sun-Shin SS
Nature communications 20171010 1
The chaperonins (CPNs) are megadalton sized hollow complexes with two cavities that open and close to encapsulate non-native proteins. CPNs are assigned to two sequence-related groups that have distinct allosteric mechanisms. In Group I CPNs a detachable co-chaperone, GroES, closes the chambers whereas in Group II a built-in lid closes the chambers. Group I CPNs have a bacterial ancestry, whereas Group II CPNs are archaeal in origin. Here we describe open and closed crystal structures representi ...[more]