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Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface-Modified Nanoporous Acupuncture Needles.


ABSTRACT: Acupuncture originated within the auspices of Oriental medicine, and today is used as an alternative method for treating various diseases and symptoms. The physiological mechanisms of acupuncture appear to involve the release of endogenous opiates and neurotransmitters, with the signals mediating through electrical stimulation of the central nervous system (CNS). Earlier we reported a nanoporous stainless steel acupuncture needle with enhanced therapeutic properties, evaluated by electrophysiological and behavioral responses in Sprague-Dawley (SD) rats. Herein, we investigate molecular changes in colorectal cancer (CRC) rats by acupuncture treatment using the nanoporous needles. Treatment at acupoint HT7 is found most effective at reducing average tumor size, ?-catenin expression levels, and the number of aberrant crypt foci in the colon endothelium. Surface modification of acupuncture needles further enhances the therapeutic effects of acupuncture treatment in CRC rats.

SUBMITTER: Lee BR 

PROVIDER: S-EPMC5635022 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface-Modified Nanoporous Acupuncture Needles.

Lee Bo Ram BR   Kim Hye-Rim HR   Choi Eun-Sook ES   Cho Jung-Hoon JH   Kim Nam-Jun NJ   Kim Jung-Hee JH   Lee Kyeong-Min KM   Razzaq Abdul A   Choi Hansaem H   Hwang Yunju Y   Grimes Craig A CA   Lee Bong-Hyo BH   Kim Eunjoo E   In Su-Il SI  

Scientific reports 20171010 1


Acupuncture originated within the auspices of Oriental medicine, and today is used as an alternative method for treating various diseases and symptoms. The physiological mechanisms of acupuncture appear to involve the release of endogenous opiates and neurotransmitters, with the signals mediating through electrical stimulation of the central nervous system (CNS). Earlier we reported a nanoporous stainless steel acupuncture needle with enhanced therapeutic properties, evaluated by electrophysiolo  ...[more]

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