Ontology highlight
ABSTRACT:
SUBMITTER: Segura-Bayona S
PROVIDER: S-EPMC5635214 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Segura-Bayona Sandra S Knobel Philip A PA González-Burón Helena H Youssef Sameh A SA Peña-Blanco Aida A Coyaud Étienne É López-Rovira Teresa T Rein Katrin K Palenzuela Lluís L Colombelli Julien J Forrow Stephen S Raught Brian B Groth Anja A de Bruin Alain A Stracker Travis H TH
Cell death and differentiation 20170714 11
The regulation of chromatin structure is critical for a wide range of essential cellular processes. The Tousled-like kinases, TLK1 and TLK2, regulate ASF1, a histone H3/H4 chaperone, and likely other substrates, and their activity has been implicated in transcription, DNA replication, DNA repair, RNA interference, cell cycle progression, viral latency, chromosome segregation and mitosis. However, little is known about the functions of TLK activity in vivo or the relative functions of the highly ...[more]