Microbial Genetic Composition Tunes Host Longevity.
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ABSTRACT:
SUBMITTER: Han B
PROVIDER: S-EPMC5635830 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Microbial Genetic Composition Tunes Host Longevity.
Han Bing B Sivaramakrishnan Priya P Lin Chih-Chun J CJ Neve Isaiah A A IAA He Jingquan J Tay Li Wei Rachel LWR Sowa Jessica N JN Sizovs Antons A Du Guangwei G Wang Jin J Herman Christophe C Wang Meng C MC
Cell 20170601 7
Homeostasis of the gut microbiota critically influences host health and aging. Developing genetically engineered probiotics holds great promise as a new therapeutic paradigm to promote healthy aging. Here, through screening 3,983 Escherichia coli mutants, we discovered that 29 bacterial genes, when deleted, increase longevity in the host Caenorhabditis elegans. A dozen of these bacterial mutants also protect the host from age-related progression of tumor growth and amyloid-beta accumulation. Mec ...[more]
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