Ontology highlight
ABSTRACT:
SUBMITTER: Clausen MV
PROVIDER: S-EPMC5635901 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Clausen Michael V MV Jarerattanachat Viwan V Carpenter Elisabeth P EP Sansom Mark S P MSP Tucker Stephen J SJ
Proceedings of the National Academy of Sciences of the United States of America 20170918 40
Living organisms perceive and respond to a diverse range of mechanical stimuli. A variety of mechanosensitive ion channels have evolved to facilitate these responses, but the molecular mechanisms underlying their exquisite sensitivity to different forces within the membrane remains unclear. TREK-2 is a mammalian two-pore domain (K2P) K<sup>+</sup> channel important for mechanosensation, and recent studies have shown how increased membrane tension favors a more expanded conformation of the channe ...[more]