Ontology highlight
ABSTRACT:
SUBMITTER: Vandereyken M
PROVIDER: S-EPMC5636116 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Vandereyken Maud M Jacques Sophie S Van Overmeire Eva E Amand Mathieu M Rocks Natacha N Delierneux Céline C Singh Pratibha P Singh Maneesh M Ghuysen Camille C Wathieu Caroline C Zurashvili Tinatin T Sounni Nor Eddine NE Moutschen Michel M Gilles Christine C Oury Cécile C Cataldo Didier D Van Ginderachter Jo A JA Rahmouni Souad S
PloS one 20171011 10
Vaccinia-H1 Related (VHR) dual-specificity phosphatase, or DUSP3, plays an important role in cell cycle regulation and its expression is altered in several human cancers. In mouse model, DUSP3 deletion prevents neo-angiogenesis and b-FGF-induced microvessel outgrowth. Considering the importance of angiogenesis in metastasis formation, our study aimed to investigate the role of DUSP3 in tumour cell dissemination. Using a Lewis Lung carcinoma (LLC) experimental metastasis model, we observed that D ...[more]