Association between ALDH2 Glu504Lys polymorphism and colorectal cancer risk: a meta-analysis.

ABSTRACT: The findings from studies on the relationship between aldehyde dehydrogenases(ALDH) gene Glu504Lys polymorphism and colorectal cancer(CRC) were inconsistent.The aim of this meta-analysis was to assess ALDH gene Glu504Lys polymorphism and CRC risk.All of the relevant studies were identified from PubMed and Embase database. Statistical analyses were conducted with STATA 12.0 software. Odds ratio (OR) with 95% confidence interval (CI) values were applied to evaluate the strength of the association. Nine studies with 2779 cases and 4533 controls were included.No significant variation in CRC risk was detected in any of the genetic models overall. To explore the sources of heterogeneity,we performed further sub-group analyses by ethnicity and quality assessment of these studies. In the sub-group analysis by race, significant associations between ALDH gene Glu504Lys polymorphism and CRC risk were found in China(Glu/Lys vs Glu/Glu: OR = 0.70, 95%CI = 0.57-0.85; the dominant model: OR =0.69, 95%CI =0.48-0.98) and Japan(Lys/Lys vs Glu/Glu:OR =0.72, 95%CI =0.55-0.95).This meta-analysis suggests that the ALDH2 Glu504Lys polymorphism may be associated with susceptibility to CRC. Furthermore, large and well-designed studies are needed to confirm these conclusions.

SUBMITTER: Xinhua J 

PROVIDER: S-EPMC5636235 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature