Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model.

ABSTRACT: The endocannabinoid system (eCBs), named after the plant Cannabis sativa, comprises cannabinoid receptors, endogenous ligands known as "endocannabinoids", and enzymes involved in the biosynthesis and degradation of these ligands, as well as putative transporters for these ligands. ECBs proteins and small molecules have been detected in early embryonic stages of many vertebrate models. As a result, cannabinoid receptors and endogenous as well as exogenous cannabinoids influence development and behavior in many vertebrate species. Understanding the precise mechanisms of action for the eCBs will provide an invaluable guide towards elucidation of vertebrate development and will also help delineate how developmental exposure to marijuana might impact health and cognitive/executive functioning i

SUBMITTER: Oltrabella F 

PROVIDER: S-EPMC5636690 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature