Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC5636748 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Chen Shaohong S Gao Guangxia G
Protein & cell 20170728 10
MicroRNAs (miRNAs) recruit the RNA-induced silencing complex (RISC) to repress the translation of target mRNAs. While the 5' 7-methylguanosine cap of target mRNAs has been well known to be important for miRNA repression, the underlying mechanism is not clear. Here we show that TNRC6A interacts with eIF4E2, a homologue of eIF4E that can bind to the cap but cannot interact with eIF4G to initiate translation, to inhibit the translation of target mRNAs. Downregulation of eIF4E2 relieved miRNA repres ...[more]