Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Csiszar A
PROVIDER: S-EPMC5636770 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
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Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer's disease.
Csiszar Anna A Tarantini Stefano S Fülöp Gábor A GA Kiss Tamas T Valcarcel-Ares M Noa MN Galvan Veronica V Ungvari Zoltan Z Yabluchanskiy Andriy A
GeroScience 20170829 4
Hypertension in the elderly substantially increases both the risk of vascular cognitive impairment (VCI) and Alzheimer's disease (AD); however, the underlying mechanisms are not completely understood. This review discusses the effects of hypertension on structural and functional integrity of cerebral microcirculation, including hypertension-induced alterations in neurovascular coupling responses, cellular and molecular mechanisms involved in microvascular damage (capillary rarefaction, blood-bra ...[more]
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