Parkinson's Disease Is Not Simply a Prion Disorder.
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ABSTRACT:
SUBMITTER: Surmeier DJ
PROVIDER: S-EPMC5637112 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Parkinson's Disease Is Not Simply a Prion Disorder.
Surmeier D James DJ Obeso José A JA Halliday Glenda M GM
The Journal of neuroscience : the official journal of the Society for Neuroscience 20171001 41
The notion that prion-like spreading of misfolded α-synuclein (α-SYN) causes Parkinson's disease (PD) has received a great deal of attention. Although attractive in its simplicity, the hypothesis is difficult to reconcile with postmortem analysis of human brains and connectome-mapping studies. An alternative hypothesis is that PD pathology is governed by regional or cell-autonomous factors. Although these factors provide an explanation for the pattern of neuronal loss in PD, they do not readily ...[more]
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