Dataset Information

Two Complete Sequences for Genomes of Human Respiratory Syncytial Virus Genotype ON1 Field Strains from Beijing, China.

ABSTRACT: Here, we report the complete sequences for genomes of two human respiratory syncytial virus field strains. It was determined by sequence alignment and phylogenetics that they belong to genotype ON1, characterized by a 72-nucleotide duplication in the C termini of the attachment protein G genes.

SUBMITTER: Cui G

PROVIDER: S-EPMC5637495 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Two Complete Sequences for Genomes of Human Respiratory Syncytial Virus Genotype ON1 Field Strains from Beijing, China.

Cui Guanglin G Zhu Runan R Deng Jie J Qian Yuan Y

Genome announcements 20171012 41

Here, we report the complete sequences for genomes of two human respiratory syncytial virus field strains. It was determined by sequence alignment and phylogenetics that they belong to genotype ON1, characterized by a 72-nucleotide duplication in the C termini of the attachment protein G genes. ...[more]

PMID: 29025935

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Project description:BackgroundThe Respiratory Syncytial Virus (RSV) A genotype ON1, which was first detected in Ontario (Canada) in 2010/11, appeared in Germany in 2011/12. Preliminary observations suggested a higher clinical severity in children infected with this new genotype. We investigated spread and disease severity of RSV-A ON1 in pediatric in- and outpatient settings.MethodsDuring 2010/11 to 2016/17, clinical characteristics and respiratory samples from children with acute respiratory tract infections (RTI) were obtained from ongoing surveillance studies in 33 pediatric practices (PP), one pediatric hospital ward (PW) and 23 pediatric intensive care units (PICU) in Germany. RSV was detected in the respiratory samples by PCR; genotypes were identified by sequencing. Within each setting, clinical severity markers were compared between RSV-A ON1 and RSV-A non-ON1 genotypes.ResultsA total of 603 children with RSV-RTI were included (132 children in PP, 288 in PW, and 183 in PICU). Of these children, 341 (56.6%) were infected with RSV-A, 235 (39.0%) with RSV-B, and one child (0.2%) with both RSV-A and RSV-B; in 26 (4.3%) children, the subtype could not be identified. In the 341 RSV-A positive samples, genotype ON1 was detected in 247 (72.4%), NA1 in 92 (26.9%), and GA5 in 2 children (0.6%). RSV-A ON1, rarely observed in 2011/12, was the predominant RSV-A genotype in all settings by 2012/13 and remained predominant until 2016/17. Children in PP or PW infected with RSV-A ON1 did not show a more severe clinical course of disease compared with RSV-A non-ON1 infections. In the PICU group, hospital stay was one day longer (median 8 days, inter-quartile range (IQR) 7-12 vs. 7 days, IQR 5-9; p = 0.02) and duration of oxygen treatment two days longer (median 6 days, IQR 4-9 vs. 4 days, IQR 2-6; p = 0.03) for children infected with RSV-A ON1.ConclusionsIn children, RSV-A ON1 largely replaced RSV-A non-ON1 genotypes within two seasons and remained the predominant RSV-A genotype in Germany during subsequent seasons. A higher clinical severity of RSV-A ON1 was observed within the group of children receiving PICU treatment, whereas in other settings clinical severity of RSV-A ON1 and non-ON1 genotypes was largely similar.

Dataset Information

Two Complete Sequences for Genomes of Human Respiratory Syncytial Virus Genotype ON1 Field Strains from Beijing, China.

Publications

Two Complete Sequences for Genomes of Human Respiratory Syncytial Virus Genotype ON1 Field Strains from Beijing, China.

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