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Chemokines encoded by herpesviruses.

ABSTRACT: Viruses use diverse strategies to elude the immune system, including copying and repurposing host cytokine and cytokine receptor genes. For herpesviruses, the chemokine system of chemotactic cytokines and receptors is a common source of copied genes. Here, we review the current state of knowledge about herpesvirus-encoded chemokines and discuss their possible roles in viral pathogenesis, as well as their clinical potential as novel anti-inflammatory agents or targets for new antiviral strategies.

SUBMITTER: Pontejo SM

PROVIDER: S-EPMC5638632 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Chemokines encoded by herpesviruses.

Pontejo Sergio M SM Murphy Philip M PM

Journal of leukocyte biology 20170828 5

Viruses use diverse strategies to elude the immune system, including copying and repurposing host cytokine and cytokine receptor genes. For herpesviruses, the chemokine system of chemotactic cytokines and receptors is a common source of copied genes. Here, we review the current state of knowledge about herpesvirus-encoded chemokines and discuss their possible roles in viral pathogenesis, as well as their clinical potential as novel anti-inflammatory agents or targets for new antiviral strategies ...[more]

PMID: 28848041

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