Ontology highlight
ABSTRACT:
SUBMITTER: Arredondo Zamarripa D
PROVIDER: S-EPMC5638810 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Arredondo Zamarripa David D Noguez Imm Ramsés R Bautista Cortés Ana María AM Vázquez Ruíz Osvaldo O Bernardini Michela M Fiorio Pla Alessandra A Gkika Dimitra D Prevarskaya Natalia N López-Casillas Fernando F Liedtke Wolfgang W Clapp Carmen C Thébault Stéphanie S
Scientific reports 20171012 1
Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retinopathy and other chronic retinal diseases, results in vasogenic edema and neural tissue damage, causing vision loss. Vasoinhibins are N-terminal fragments of prolactin that prevent BRB breakdown during diabetes. They modulate the expression of some transient receptor potential (TRP) family members, yet their role in regulating the TRP vanilloid subtype 4 (TRPV4) remains unknown. TRPV4 is a calcium-permeable channel involved ...[more]