Ontology highlight
ABSTRACT:
SUBMITTER: Newson J
PROVIDER: S-EPMC5639146 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Newson Justine J Motwani Madhur P MP Kendall Alexandra C AC Nicolaou Anna A Muccioli Giulio G GG Alhouayek Mireille M Bennett Melanie M Van De Merwe Rachel R James Sarah S De Maeyer Roel P H RPH Gilroy Derek W DW
Cell reports 20170901 13
Acute inflammation is characterized by granulocyte infiltration followed by efferocytosing mononuclear phagocytes, which pave the way for inflammatory resolution. Until now, it was believed that resolution then leads back to homeostasis, the physiological state tissues experience before inflammation occurred. However, we discovered that resolution triggered a prolonged phase of immune suppression mediated by prostanoids. Specifically, once inflammation was switched off, natural killer cells, sec ...[more]