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Expression of glucose transporters in the developing rat skin.


ABSTRACT: We found the changed distribution of glucose transporter (GLUT) proteins in the skin during rat development. At 15 days of gestation, GLUT1 and 2 proteins were expressed in the stratum corneum of epidermal cells. In postnatal skin, however, GLUT1 and 2 exhibit different expression patterns. While GLUT1 expression becomes more restricted to the stratum basale with development, GLUT2 was found mainly in stratum spinosum and granulosum, but not being localized in the stratum basale at any stages of perinatal skin development. Considering all these, it can be speculated that each GLUT protein plays its specific role in different epidermal layers and that the glucose used in mammalian skin in utero could be originated from the amniotic fluid during skin development.

SUBMITTER: Oh CS 

PROVIDER: S-EPMC5639176 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Expression of glucose transporters in the developing rat skin.

Oh Chang Seok CS   Hong Jong Ha JH   Jin Shun Nu SN   Lee Wang Jae WJ   Lee Young Soo YS   Lee Eunju E  

Anatomy & cell biology 20170920 3


We found the changed distribution of glucose transporter (GLUT) proteins in the skin during rat development. At 15 days of gestation, GLUT1 and 2 proteins were expressed in the <i>stratum corneum</i> of epidermal cells. In postnatal skin, however, GLUT1 and 2 exhibit different expression patterns. While GLUT1 expression becomes more restricted to the <i>stratum basale</i> with development, GLUT2 was found mainly in <i>stratum spinosum</i> and <i>granulosum</i>, but not being localized in the <i>  ...[more]

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