Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC5639290 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Li Huaibiao H Kroll Torsten T Moll Jürgen J Frappart Lucien L Herrlich Peter P Heuer Heike H Ploubidou Aspasia A
Stem cell reports 20170921 4
Misoriented division of neuroprogenitors, by loss-of-function studies of centrosome or spindle components, has been linked to the developmental brain defects microcephaly and lissencephaly. As these approaches also affect centrosome biogenesis, spindle assembly, or cell-cycle progression, the resulting pathologies cannot be attributed solely to spindle misorientation. To address this issue, we employed a truncation of the spindle-orienting protein RHAMM. This truncation of the RHAMM centrosome-t ...[more]