Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC5639430 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Stem cell reports 20170928 4
Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and other tauopathies. High-throughput screening in neurons derived from human induced pluripotent stem cells (iPSCs) is a powerful tool to identify tau-targeted therapeutics. However, such screens have been hampered by heterogeneous neuronal production, high cost and low yield, and multi-step differentiation procedures. We engineered an isogenic iPSC line that harbors an inducible neurogenin 2 transgene, a t ...[more]