Ontology highlight
ABSTRACT:
SUBMITTER: Edupuganti RR
PROVIDER: S-EPMC5639460 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Edupuganti Raghu Ram RR Harikumar Arigela A Aaronson Yair Y Biran Alva A Sailaja Badi Sri BS Nissim-Rafinia Malka M Azad Gajendra Kumar GK Cohen Malkiel A MA Park Jung Eun JE Shivalila Chikdu S CS Markoulaki Styliani S Sze Siu Kwan SK Jaenisch Rudolf R Meshorer Eran E
Stem cell reports 20170928 4
Embryonic stem cells (ESCs) are regulated by pluripotency-related transcription factors in concert with chromatin regulators. To identify additional stem cell regulators, we screened a library of endogenously labeled fluorescent fusion proteins in mouse ESCs for fluorescence loss during differentiation. We identified SET, which displayed a rapid isoform shift during early differentiation from the predominant isoform in ESCs, SETα, to the primary isoform in differentiated cells, SETβ, through alt ...[more]