Ontology highlight
ABSTRACT:
SUBMITTER: Skamagki M
PROVIDER: S-EPMC5639470 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Stem cell reports 20171001 4
The RNA exosome complex targets AU-rich element (ARE)-containing mRNAs in eukaryotic cells. We identified a transcription factor, ZSCAN10, which binds to the promoters of multiple RNA exosome complex subunits in pluripotent stem cells to maintain subunit gene expression. We discovered that induced pluripotent stem cell clones generated from aged tissue donors (A-iPSC) show poor expression of ZSCAN10, leading to poor RNA exosome complex expression, and a subsequent elevation in ARE-containing RNA ...[more]