Ontology highlight
ABSTRACT:
SUBMITTER: Dogan S
PROVIDER: S-EPMC5639875 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Dogan Snjezana S Chute Deborah J DJ Xu Bin B Ptashkin Ryan N RN Chandramohan Raghu R Casanova-Murphy Jacklyn J Nafa Khedoudja K Bishop Justin A JA Chiosea Simion I SI Stelow Edward B EB Ganly Ian I Pfister David G DG Katabi Nora N Ghossein Ronald A RA Berger Michael F MF
The Journal of pathology 20170609 4
Sinonasal undifferentiated carcinoma (SNUC) is a high-grade malignancy with limited treatment options and poor outcome. A morphological spectrum of 47 sinonasal tumours including 17 (36.2%) SNUCs was analysed at genomic level. Thirty carcinomas (cohort 1) were subjected to a hybridization exon-capture next-generation sequencing assay (MSK-IMPACT<sup>TM</sup> ) to interrogate somatic variants in 279 or 410 cancer-related genes. Seventeen sinonasal tumours (cohort 2) were examined only for the pre ...[more]