Dataset Information

Infant BMI peak as a predictor of overweight and obesity at age 2 years in a Chinese community-based cohort.

ABSTRACT:

Objectives

Infant body mass index (BMI) peak has proven to be a useful indicator for predicting childhood obesity risk in American and European populations. However, it has not been assessed in China. We characterised infant BMI trajectories in a Chinese longitudinal cohort and evaluated whether BMI peak can predict overweight and obesity at age 2 years.

Methods

Serial measurements (n=6-12) of weight and length were taken from healthy term infants (n=2073) in a birth cohort established in urban Shanghai. Measurements were used to estimate BMI growth curves from birth to 13.5 months using a polynomial regression model. BMI peak characteristics, including age (in months) and magnitude (BMI, in kg/m²) at peak and prepeak velocities (in kg/m²/month), were estimated. The relationship between infant BMI peak and childhood BMI at age 2 years was examined using binary logistic analysis.

Results

Mean age at peak BMI was 7.61 months, with a magnitude of 18.33?kg/m². Boys (n=1022) had a higher average peak BMI (18.60 vs 18.07?kg/m², p<0.001) and earlier average achievement of peak value (7.54 vs 7.67 months, p<0.05) than girls (n=1051). With 1?kg/m² increase in peak BMI and 1?month increase in peak time, the risk of overweight at age 2 years increased by 2.11 times (OR 3.11; 95%?CI 2.64 to 3.66) and 35% (OR 1.35; 95%?CI 1.21 to 1.50), respectively. Similarly, higher BMI magnitude (OR 2.69; 95%?CI 2.00 to 3.61) and later timing of infant BMI peak (OR 1.35; 95%?CI 1.08 to 1.68) were associated with an increased risk of childhood obesity at age 2 years.

Conclusions

We have shown that infant BMI peak is valuable for predicting early childhood overweight and obesity in urban Shanghai. Because this is the first Chinese community-based cohort study of this nature, future research is required to examine infant populations in other areas of China.

SUBMITTER: Sun J

PROVIDER: S-EPMC5640041 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Infant BMI peak as a predictor of overweight and obesity at age 2 years in a Chinese community-based cohort.

Sun Jie J Nwaru Bright I BI Hua Jing J Li Xiaohong X Wu Zhuochun Z

BMJ open 20171006 10

<h4>Objectives</h4>Infant body mass index (BMI) peak has proven to be a useful indicator for predicting childhood obesity risk in American and European populations. However, it has not been assessed in China. We characterised infant BMI trajectories in a Chinese longitudinal cohort and evaluated whether BMI peak can predict overweight and obesity at age 2 years.<h4>Methods</h4>Serial measurements (n=6-12) of weight and length were taken from healthy term infants (n=2073) in a birth cohort establ ...[more]

PMID: 28988164

Similar Datasets

Project description:BACKGROUND:The study of epigenetic processes and mechanisms present a dynamic approach to assess complex individual variation in obesity susceptibility. However, few studies have examined epigenetic patterns in preschool-age children at-risk for obesity despite the relevance of this developmental stage to trajectories of weight gain. We hypothesized that salivary DNA methylation patterns of key obesogenic genes in Hispanic children would 1) correlate with maternal BMI and 2) allow for identification of pathways associated with children at-risk for obesity. RESULTS:Genome-wide DNA methylation was conducted on 92 saliva samples collected from Hispanic preschool children using the Infinium Illumina HumanMethylation 450 K BeadChip (Illumina, San Diego, CA, USA), which interrogates >484,000 CpG sites associated with ~24,000 genes. The analysis was limited to 936 genes that have been associated with obesity in a prior GWAS Study. Child DNA methylation at 17 CpG sites was found to be significantly associated with maternal BMI, with increased methylation at 12 CpG sites and decreased methylation at 5 CpG sites. Pathway analysis revealed methylation at these sites related to homocysteine and methionine degradation as well as cysteine biosynthesis and circadian rhythm. Furthermore, eight of the 17 CpG sites reside in genes (FSTL1, SORCS2, NRF1, DLC1, PPARGC1B, CHN2, NXPH1) that have prior known associations with obesity, diabetes, and the insulin pathway. CONCLUSIONS:Our study confirms that saliva is a practical human tissue to obtain in community settings and in pediatric populations. These salivary findings indicate potential epigenetic differences in Hispanic preschool children at risk for pediatric obesity. Identifying early biomarkers and understanding pathways that are epigenetically regulated during this critical stage of child development may present an opportunity for prevention or early intervention for addressing childhood obesity. TRIAL REGISTRATION:The clinical trial protocol is available at ClinicalTrials.gov ( NCT01316653 ). Registered 3 March 2011.

Dataset Information

Infant BMI peak as a predictor of overweight and obesity at age 2 years in a Chinese community-based cohort.

Objectives

Methods

Results

Conclusions

Publications

Infant BMI peak as a predictor of overweight and obesity at age 2 years in a Chinese community-based cohort.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets