Risk and adverse outcomes of fractures in patients with liver cirrhosis: two nationwide retrospective cohort studies.

ABSTRACT:

Objective

The aim of this study is to evaluate fracture risk and post-fracture outcomes in patients with and without liver cirrhosis (LC).

Design

Retrospective cohort study and nested fracture cohort study.

Setting

This study was based on Taiwan's National Health Insurance Research Database that included information on: (1) 3941 patients aged 20 years and older newly diagnosed with LC between 2000 and 2003; (2) 688290 hospitalised fracture patients aged 20 years and older between 2006 and 2013.

Primary and secondary outcome measures

Followed-up events of fracture from 2000 to 2008 were noted from medical claims to evaluate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of fracture associated with LC. Adjusted odds ratios (ORs) and 95% CIs of ad

SUBMITTER: Chen TL 

PROVIDER: S-EPMC5640047 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature