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Sodium excretion is higher in patients with rheumatoid arthritis than in matched controls.

ABSTRACT: It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls.This case-control study included 24 patients with RA at diagnosis and 24 controls matched by age, gender and body mass index. Sodium intake was evaluated by 24-hr urinary sodium excretion.Sodium excretion was greater for patients with early RA (2,849±1,350 vs. 2,182±751.7mg/day, p = 0.039) than controls. This difference remained significant after adjustment for smoking and the use of anti-hypertensive and nonsteroidal anti-inflammatory drugs (p = 0.043). Patients with radiographic erosion at the time of diagnosis had a higher sodium excretion than those without (p = 0.028).Patients with early RA showed increased sodium excretion which may have contributed to autoimmunity.

SUBMITTER: Marouen S

PROVIDER: S-EPMC5640209 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Sodium excretion is higher in patients with rheumatoid arthritis than in matched controls.

Marouen Sarah S du Cailar Guilhem G Audo Rachel R Lukas Cedric C Vial Gaelle G Tournadre Anne A Barrat Emmanuel E Ribstein Jean J Combe Bernard B Morel Jacques J Daien Claire I CI

PloS one 20171013 10

<h4>Objective</h4>It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls.<h4>Methods</h4>This case-control study included 24 patients with RA at diagnosis and 24 controls matched by age, gender and body mass index. Sodium intake was evaluated by 24-hr urinary sodium excretion.<h4>Results</h4>Sodium excretion was greater for patients with early RA (2,849±1,350 ...[more]

PMID: 29028829

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